ANTIOXIDANT PROPERTIES OF BOVINE COLOSTRUM AND ITS MAIN BIOACTIVE CONSTITUENTS OF LACTOFERRIN AND LACTOPEROXIDASE

Document Type : Original Article

Authors

1 Food Science and Nutritional depart. Faculty Home Economics, Minofiya University

2 Animal Production Depart. Faculty of Agric. Cairo University.

Abstract

Bovine colostrum and its protective bioactive constituents lactoferrin and lactoperoxidase have been shown to prevent oxidant -induced injury of endothelial cells. The aim of present  study was to determine the effects of a dietary bovine colostrum on the generation of  hydrogen peroxide (H2O2) and superoxide anion(O2) and the activity of three antioxidant enzymes in a bovine pulmonary artery endothelial cell line (PAEC). All of the examined colostrum fraction forms exhibited a clear and potent antioxidant activity by increasing significantly the activity of all antioxidant enzymes in a dose and time-dependent fashion. The results suggested that dietary bovine colostrum and its constituents may be effective antioxidants in preventing or treating endothelial ceil injury associated with reactive oxygen species (ROS).