EI-Daly,, E., Abo Hagger, A., Hassan, N., Abdel Shafea, Y. (2005). INFLUENCE OF SOME ANTIOXIDANTS ON HISTOPATHOLOGICAL ALTERATION OF AFLATOXINS.. Journal of Animal and Poultry Production, 30(9), 5043-5058. doi: 10.21608/jappmu.2005.238035
E. S. EI-Daly,; Amal A. Abo Hagger; Nabila S. Hassan; Y. M. Abdel Shafea. "INFLUENCE OF SOME ANTIOXIDANTS ON HISTOPATHOLOGICAL ALTERATION OF AFLATOXINS.". Journal of Animal and Poultry Production, 30, 9, 2005, 5043-5058. doi: 10.21608/jappmu.2005.238035
EI-Daly,, E., Abo Hagger, A., Hassan, N., Abdel Shafea, Y. (2005). 'INFLUENCE OF SOME ANTIOXIDANTS ON HISTOPATHOLOGICAL ALTERATION OF AFLATOXINS.', Journal of Animal and Poultry Production, 30(9), pp. 5043-5058. doi: 10.21608/jappmu.2005.238035
EI-Daly,, E., Abo Hagger, A., Hassan, N., Abdel Shafea, Y. INFLUENCE OF SOME ANTIOXIDANTS ON HISTOPATHOLOGICAL ALTERATION OF AFLATOXINS.. Journal of Animal and Poultry Production, 2005; 30(9): 5043-5058. doi: 10.21608/jappmu.2005.238035
INFLUENCE OF SOME ANTIOXIDANTS ON HISTOPATHOLOGICAL ALTERATION OF AFLATOXINS.
1Dept. Of Zoology, Fac. of Science, Helwan Univ., Egypt.
2Central Lab. Of Food and Feed, Ministry of Agriculture, Giza, Egypt.
3Dept. of Pathology, National Research Center, Dokki, Egypt.
Abstract
The present study was designed to evaluate the protective role of vitamin E &. selenium (Se). vitamin A, vitamin C, and choline and their combination against the harmful histological effects of anatoxin in rats. Adurt male albino rats, weighing 80·120 g were divided into similar groups. Rats fed 3 anatoxin doses being 5, 10 and 20 mg/Kg diet (3 positive control groups). Aflatoxin plus vitamin E (0.5 mg/kg diet) e. Se (S~g/I drinking water), vitamin C (2 g/kg diet), vitamin A (500 m[U Ikg diet), choline (3 g/kg diet) and vitamins combination with choline at the same levels mentioned belore. Each one from the live pretreatment groups is subdivided into three subgroups according to doses of anatoxin (treated groups). The negative control group received normal basal diet. Rats received aftatoxins with or without vitamins for 60 days then scarified and liver and kidney were taken for histopathological examination.
The histopathological examination of liver of rats treated by aflatoxins revealed vascular dilatation, congestion, edema, hepatic cords disorganization, aggregation of infiammatory cells, pyknotic nuclei and at the highest aflatoxins dose revealed focal necrosis, destruction or bile duct epithelial cells and pleomorphic and necrotic nuclei. The lesions showed increase in severity in a dose dependent manner, However, kidney revealed damaged glomeruli, cloudy swelling in epithelial lining tubules, interstitial hemorrhage and cellular infiltration, beside prominent degeneration in renal tubules and glomeruli at the high doses. The lesions were dose dependent.
The present study suggested that, administration of vitamins and choline resul\w in reducing the toxic effects of afta\oxins on liver and Kidneys, The best improvements in liver and kidney tissues were shown in groups treated by vitamin E + Se and groups treated by the antioxidants mixture,
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