Abdel-Latif, M., Elmeleigy, K., Khattab, M., Mohamd, S. (2016). Hepatoprotective Effect of Coumarin and Chlorophyll Against Aflatoxicosis in Rat. Journal of Animal and Poultry Production, 7(12), 483-490. doi: 10.21608/jappmu.2016.48813
M. S. Abdel-Latif; K. M. Elmeleigy; Marwa M. S. Khattab; Sara M. Mohamd. "Hepatoprotective Effect of Coumarin and Chlorophyll Against Aflatoxicosis in Rat". Journal of Animal and Poultry Production, 7, 12, 2016, 483-490. doi: 10.21608/jappmu.2016.48813
Abdel-Latif, M., Elmeleigy, K., Khattab, M., Mohamd, S. (2016). 'Hepatoprotective Effect of Coumarin and Chlorophyll Against Aflatoxicosis in Rat', Journal of Animal and Poultry Production, 7(12), pp. 483-490. doi: 10.21608/jappmu.2016.48813
Abdel-Latif, M., Elmeleigy, K., Khattab, M., Mohamd, S. Hepatoprotective Effect of Coumarin and Chlorophyll Against Aflatoxicosis in Rat. Journal of Animal and Poultry Production, 2016; 7(12): 483-490. doi: 10.21608/jappmu.2016.48813
Hepatoprotective Effect of Coumarin and Chlorophyll Against Aflatoxicosis in Rat
1Biochemistry Department, Faculty of Agriculture, Cairo University, Giza, Egypt.
2Regional Center For Food and Feed, Agricultural Research Center, Ministry of Agriculture, Giza, Egypt.
3Department of Pathology, Fac. of Veterinary Medicine, Cairo University, Giza Square, Giza, Egypt. Postal code 12211
Abstract
Aflatoxin contamination of animal diet is still a major problem for breeders since it hasadverse effects on animal health and productivity. This study was carried out to investigate the effect of using coumarin and/or chlorophyll in rat diet against aflatoxicosis. Fifty four rats were randomly assigned into 7 groups ''6 rats each'' and group 5 ''12 rats''. Group 1 was negative control. Group 2 received water with coumarin 0.5%. Group 3 received water with chlorophyll 0.5%. Group 4 received water with coumarin 0.5% and chlorophyll 0.5%. Group 5-8 received basal diet with aflatoxin B1 1000 ppb. Group 6-8 were administered similar treatments as groups 2-4. The experiment ended after 8 weeks. Water and feed consumption were measured and feed conversion rate were calculated. Random glucose level, total lipid, total cholesterol, triglyceride, total protein, ALT , AST, creatinine and urea were determined in serum. Histopathological examination of liver, kidney and pancreas was performed. The conversion rate was significantly low in group 5 compared to groups 6-8. The serum glucose, cholesterol, AST and ALT were elevated in group 5 compared to groups 6-8. The liver lesions observed in group 5 represented in vacuolation and necrosis were alleviated in groups 6-8. The necrosis and inflammatory cells infiltration in pancreas of group 5 were absent in groups 6-8. In conclusion, the coumarin and or chlorophyll possessed a hepatoprotective effect against aflatoxincosis.
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